Comparison of intracranial hemorrhagic prevalence between Clopidogrel and Warfarin used in mild head injury patients.
Background:
The prevalence of intracranial hemorrhage in Thai population who used Clopidogrel in mild head injury patients is unknown. This knowledge is important for physician to evaluate intracerebral hemorrhage risk and decision making in the emergency room.
Objective:
To Compare the risk of intracranial hemorrhage (ICH) between Clopidogrel and Warfarin used in mild head injury patients.
Method:
A prospective cross-sectional study was conducted among mild head injury patients, who used Clopidogrel or Warfarin within one week prior to the injury, visited the emergency department of Ramathibodi hospital between1st August 2014 and 30th September 2015 (pilot study). The primary outcome was prevalence of intracranial hemorrhagic and complication within 72 hours.
Results:
34 mild head injury patients were enrolled, 15 patients were taking Warfarin and 19 patients were taking Cloplidogrel.All patients underwent CT scan, 5 patientshad intracerebral hemorrhage, 2 patients were taking warfarin and 3 patients were taking Clopidogrel, prevalence were 13.33% and 15.79% respectively (Odd Ratio 0.82, 95% CI 0.15-5.67). No mortality at 24-72 hours after injury. All intracerebral hemorrhage patients in warfarin group had neurosurgical intervention, but all patients in Clopidogrel group had conservative treatment.
Conclusion:
Mild Head injury Patients who were taking Clopidogrel might had higher risk of Intracranial bleeding than those who were taking warfarin, but latter group required more neurosurgical intervention.